FIB-4 calculator
Estimate the likelihood of advanced liver fibrosis from age, platelets, AST and ALT, without a biopsy.
Your result appears here as you type.
The formula
FIB-4 = (age × AST) ÷ (platelets × √ALT). AST and ALT are in U/L, and platelets in 10⁹/L.
Reading the score
Cut-offs vary by liver disease and guideline. In people aged 65 and over, a lower cut-off of 2.0 is often used. Hepatitis flares and other causes of raised AST can distort the score.
| FIB-4 | Meaning |
|---|---|
| Below 1.3 | Advanced fibrosis unlikely |
| 1.3 to 2.67 | Indeterminate, consider further tests |
| Above 2.67 | Advanced fibrosis more likely |
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See the featuresCommon questions
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What is a normal FIB-4 score?
There is no single normal value. Below 1.3 suggests advanced fibrosis is unlikely.
Can FIB-4 diagnose cirrhosis?
No. It is a screening score. Follow up a raised result with elastography or specialist review.
Is FIB-4 useful for hepatitis C?
Yes. It was first developed in people with HIV and hepatitis C coinfection, and it is widely used in viral hepatitis and fatty liver disease.
Try it with next week’s patients
Plans start at PKR 4,000 a month, billed in rupees, with setup and staff training included. Bring over next week’s patients and see whether the evening session runs any easier.
Setup help and staff training are included on every plan.